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Physiologically based modelling of the antiplatelet effect of aspirin: A tool to characterize drug responsiveness and inform precision dosing

A computational approach involving mathematical modeling and in silico experiments was used to characterize the determinants of extent and duration of platelet cyclooxygenase (COX)-1 inhibition by aspirin and design precision dosing in patients with accelerated platelet turnover or reduced drug bioa...

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Detalles Bibliográficos
Autores principales:	Giaretta, Alberto, Petrucci, Giovanna, Rocca, Bianca, Toffolo, Gianna Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385056/ https://www.ncbi.nlm.nih.gov/pubmed/35976924 http://dx.doi.org/10.1371/journal.pone.0268905

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