Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach

[Image: see text] MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing e...

Descripción completa

Detalles Bibliográficos
Autores principales: Paymode, Dinesh J., Chang, Le, Chen, Dan, Wang, Binglin, Kashinath, Komirishetty, Gopalsamuthiram, Vijayagopal, McQuade, D. Tyler, Vasudevan, N., Ahmad, Saeed, Snead, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385109/
https://www.ncbi.nlm.nih.gov/pubmed/34185545
http://dx.doi.org/10.1021/acs.orglett.1c01725
Descripción
Sumario:[Image: see text] MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.

Ejemplares similares