Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach

[Image: see text] MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing e...

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Autores principales: Paymode, Dinesh J., Chang, Le, Chen, Dan, Wang, Binglin, Kashinath, Komirishetty, Gopalsamuthiram, Vijayagopal, McQuade, D. Tyler, Vasudevan, N., Ahmad, Saeed, Snead, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385109/
https://www.ncbi.nlm.nih.gov/pubmed/34185545
http://dx.doi.org/10.1021/acs.orglett.1c01725
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author Paymode, Dinesh J.
Chang, Le
Chen, Dan
Wang, Binglin
Kashinath, Komirishetty
Gopalsamuthiram, Vijayagopal
McQuade, D. Tyler
Vasudevan, N.
Ahmad, Saeed
Snead, David R.
author_facet Paymode, Dinesh J.
Chang, Le
Chen, Dan
Wang, Binglin
Kashinath, Komirishetty
Gopalsamuthiram, Vijayagopal
McQuade, D. Tyler
Vasudevan, N.
Ahmad, Saeed
Snead, David R.
author_sort Paymode, Dinesh J.
collection PubMed
description [Image: see text] MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.
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spelling pubmed-93851092022-08-18 Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach Paymode, Dinesh J. Chang, Le Chen, Dan Wang, Binglin Kashinath, Komirishetty Gopalsamuthiram, Vijayagopal McQuade, D. Tyler Vasudevan, N. Ahmad, Saeed Snead, David R. Org Lett [Image: see text] MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers. American Chemical Society 2021-06-29 2021-07-16 /pmc/articles/PMC9385109/ /pubmed/34185545 http://dx.doi.org/10.1021/acs.orglett.1c01725 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Paymode, Dinesh J.
Chang, Le
Chen, Dan
Wang, Binglin
Kashinath, Komirishetty
Gopalsamuthiram, Vijayagopal
McQuade, D. Tyler
Vasudevan, N.
Ahmad, Saeed
Snead, David R.
Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title_full Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title_fullStr Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title_full_unstemmed Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title_short Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
title_sort application of vinamidinium salt chemistry for a palladium free synthesis of anti-malarial mmv048: a “bottom-up” approach
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385109/
https://www.ncbi.nlm.nih.gov/pubmed/34185545
http://dx.doi.org/10.1021/acs.orglett.1c01725
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