Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions

The helicase XPD is known as a key subunit of the DNA repair/transcription factor TFIIH. However, here, we report that XPD, independently to other TFIIH subunits, can localize with the motor kinesin Eg5 to mitotic spindles and the midbodies of human cells. The XPD/Eg5 partnership is promoted upon ph...

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Detalles Bibliográficos
Autores principales: Compe, Emmanuel, Pangou, Evanthia, Le May, Nicolas, Elly, Clémence, Braun, Cathy, Hwang, Ji-Hyun, Coin, Frédéric, Sumara, Izabela, Choi, Kwang-Wook, Egly, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Earth, Environmental, Ecological, and Space Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385140/
https://www.ncbi.nlm.nih.gov/pubmed/35977011
http://dx.doi.org/10.1126/sciadv.abp9457

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