A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts

Telomeres are repetitive nucleotide sequences at the ends of each chromosome. It has been hypothesized that telomere attrition evolved as a tumor suppressor mechanism in large long-lived species. Long telomeres can silence genes millions of bases away through a looping mechanism called telomere posi...

Descripción completa

Detalles Bibliográficos
Autores principales: Jäger, Kathrin, Mensch, Juliane, Grimmig, Maria Elisabeth, Neuner, Bruno, Gorzelniak, Kerstin, Türkmen, Seval, Demuth, Ilja, Hartmann, Alexander, Hartmann, Christiane, Wittig, Felix, Sporbert, Anje, Hermann, Andreas, Fuellen, Georg, Möller, Steffen, Walter, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385144/
https://www.ncbi.nlm.nih.gov/pubmed/35977016
http://dx.doi.org/10.1126/sciadv.abk2814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385144/
https://www.ncbi.nlm.nih.gov/pubmed/35977016
http://dx.doi.org/10.1126/sciadv.abk2814

Ejemplares similares