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A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts
Telomeres are repetitive nucleotide sequences at the ends of each chromosome. It has been hypothesized that telomere attrition evolved as a tumor suppressor mechanism in large long-lived species. Long telomeres can silence genes millions of bases away through a looping mechanism called telomere posi...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385144/ https://www.ncbi.nlm.nih.gov/pubmed/35977016 http://dx.doi.org/10.1126/sciadv.abk2814 |