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The evolving role of tissue-resident memory T cells in infections and cancer

Resident memory T cells (T(RM)) form a distinct type of T memory cells that stably resides in tissues. T(RM) form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses mediated by pathogens, cancer, and possibly au...

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Autores principales: Yenyuwadee, Sasitorn, Sanchez-Trincado Lopez, Jose Luis, Shah, Rushil, Rosato, Pamela C., Boussiotis, Vassiliki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385156/
https://www.ncbi.nlm.nih.gov/pubmed/35977028
http://dx.doi.org/10.1126/sciadv.abo5871
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author Yenyuwadee, Sasitorn
Sanchez-Trincado Lopez, Jose Luis
Shah, Rushil
Rosato, Pamela C.
Boussiotis, Vassiliki A.
author_facet Yenyuwadee, Sasitorn
Sanchez-Trincado Lopez, Jose Luis
Shah, Rushil
Rosato, Pamela C.
Boussiotis, Vassiliki A.
author_sort Yenyuwadee, Sasitorn
collection PubMed
description Resident memory T cells (T(RM)) form a distinct type of T memory cells that stably resides in tissues. T(RM) form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses mediated by pathogens, cancer, and possibly autoantigens during autoimmunity. T(RM) express residence gene signatures, functional properties of both memory and effector cells, and remarkable plasticity. T(RM) have a well-established role in pathogen immunity, whereas their role in antitumor immune responses and immunotherapy is currently evolving. As T(RM) form the most abundant T memory cell population in nonlymphoid tissues, they are attractive targets for therapeutic exploitation. Here, we provide a concise review of the development and physiological role of CD8(+) T(RM), their involvement in diseases, and their potential therapeutic exploitation.
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spelling pubmed-93851562022-08-26 The evolving role of tissue-resident memory T cells in infections and cancer Yenyuwadee, Sasitorn Sanchez-Trincado Lopez, Jose Luis Shah, Rushil Rosato, Pamela C. Boussiotis, Vassiliki A. Sci Adv Biomedicine and Life Sciences Resident memory T cells (T(RM)) form a distinct type of T memory cells that stably resides in tissues. T(RM) form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses mediated by pathogens, cancer, and possibly autoantigens during autoimmunity. T(RM) express residence gene signatures, functional properties of both memory and effector cells, and remarkable plasticity. T(RM) have a well-established role in pathogen immunity, whereas their role in antitumor immune responses and immunotherapy is currently evolving. As T(RM) form the most abundant T memory cell population in nonlymphoid tissues, they are attractive targets for therapeutic exploitation. Here, we provide a concise review of the development and physiological role of CD8(+) T(RM), their involvement in diseases, and their potential therapeutic exploitation. American Association for the Advancement of Science 2022-08-17 /pmc/articles/PMC9385156/ /pubmed/35977028 http://dx.doi.org/10.1126/sciadv.abo5871 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Yenyuwadee, Sasitorn
Sanchez-Trincado Lopez, Jose Luis
Shah, Rushil
Rosato, Pamela C.
Boussiotis, Vassiliki A.
The evolving role of tissue-resident memory T cells in infections and cancer
title The evolving role of tissue-resident memory T cells in infections and cancer
title_full The evolving role of tissue-resident memory T cells in infections and cancer
title_fullStr The evolving role of tissue-resident memory T cells in infections and cancer
title_full_unstemmed The evolving role of tissue-resident memory T cells in infections and cancer
title_short The evolving role of tissue-resident memory T cells in infections and cancer
title_sort evolving role of tissue-resident memory t cells in infections and cancer
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385156/
https://www.ncbi.nlm.nih.gov/pubmed/35977028
http://dx.doi.org/10.1126/sciadv.abo5871
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