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Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study

PURPOSE: Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes. PATIENTS AND METHODS: This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glauco...

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Autores principales: Nassiri, Nariman, Das, Shibandri, Patel, Vaama, Nirmalan, Aravindh, Patwa, Dhir, Heriford, Alexandra, Kim, Chaesik, Chen, Haoxing, Ridha, Faisal, Tannir, Justin, Goyal, Anju, Juzych, Mark S, Hughes, Bret A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385390/
https://www.ncbi.nlm.nih.gov/pubmed/36060045
http://dx.doi.org/10.5005/jp-journals-10078-1350
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author Nassiri, Nariman
Das, Shibandri
Patel, Vaama
Nirmalan, Aravindh
Patwa, Dhir
Heriford, Alexandra
Kim, Chaesik
Chen, Haoxing
Ridha, Faisal
Tannir, Justin
Goyal, Anju
Juzych, Mark S
Hughes, Bret A
author_facet Nassiri, Nariman
Das, Shibandri
Patel, Vaama
Nirmalan, Aravindh
Patwa, Dhir
Heriford, Alexandra
Kim, Chaesik
Chen, Haoxing
Ridha, Faisal
Tannir, Justin
Goyal, Anju
Juzych, Mark S
Hughes, Bret A
author_sort Nassiri, Nariman
collection PubMed
description PURPOSE: Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes. PATIENTS AND METHODS: This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glaucoma suspect eyes (i.e., concerning cup-to-disk ratio and/or intraocular pressure (IOP) >21 mm Hg), age ≥ 30 years old, follow-up time of 5 years, best-corrected visual acuity (BCVA) of 20/100 or better, spherical equivalent (SE) higher than 8 diopters and an astigmatism less than 3 diopters. Eyes with glaucoma—determined by two consecutive, reliable visual field tests—were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not. RESULTS: In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression. CONCLUSION: Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes. HOW TO CITE THIS ARTICLE: Nassiri N, Das S, Patel V, et al. Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. J Curr Glaucoma Pract 2022;16(1):11-16.
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spelling pubmed-93853902022-09-02 Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study Nassiri, Nariman Das, Shibandri Patel, Vaama Nirmalan, Aravindh Patwa, Dhir Heriford, Alexandra Kim, Chaesik Chen, Haoxing Ridha, Faisal Tannir, Justin Goyal, Anju Juzych, Mark S Hughes, Bret A J Curr Glaucoma Pract Original Research PURPOSE: Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes. PATIENTS AND METHODS: This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glaucoma suspect eyes (i.e., concerning cup-to-disk ratio and/or intraocular pressure (IOP) >21 mm Hg), age ≥ 30 years old, follow-up time of 5 years, best-corrected visual acuity (BCVA) of 20/100 or better, spherical equivalent (SE) higher than 8 diopters and an astigmatism less than 3 diopters. Eyes with glaucoma—determined by two consecutive, reliable visual field tests—were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not. RESULTS: In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression. CONCLUSION: Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes. HOW TO CITE THIS ARTICLE: Nassiri N, Das S, Patel V, et al. Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. J Curr Glaucoma Pract 2022;16(1):11-16. Jaypee Brothers Medical Publishers 2022 /pmc/articles/PMC9385390/ /pubmed/36060045 http://dx.doi.org/10.5005/jp-journals-10078-1350 Text en Copyright © 2022; The Author(s). https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2022 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Research
Nassiri, Nariman
Das, Shibandri
Patel, Vaama
Nirmalan, Aravindh
Patwa, Dhir
Heriford, Alexandra
Kim, Chaesik
Chen, Haoxing
Ridha, Faisal
Tannir, Justin
Goyal, Anju
Juzych, Mark S
Hughes, Bret A
Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title_full Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title_fullStr Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title_full_unstemmed Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title_short Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study
title_sort factors associated with 5-year glaucomatous progression in glaucoma suspect eyes: a retrospective longitudinal study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385390/
https://www.ncbi.nlm.nih.gov/pubmed/36060045
http://dx.doi.org/10.5005/jp-journals-10078-1350
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