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Differential impact of tumor suppressor gene (TP53, PTEN, RB1) alterations and treatment outcomes in metastatic, hormone-sensitive prostate cancer

BACKGROUND: Altered tumor suppressor genes (TSG-alt) in prostate cancer are associated with worse outcomes. The prognostic value of TSG-alt in metastatic, hormone-sensitive prostate cancer (M1-HSPC) is unknown. We evaluated the effects of TSG-alt on outcomes in M1-HSPC and their prognostic impact by...

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Detalles Bibliográficos
Autores principales:	Velez, Miguel Gonzalez, Kosiorek, Heidi E., Egan, Jan B., McNatty, Andrea L., Riaz, Irbaz B., Hwang, Steven R., Stewart, Glenn A., Ho, Thai H., Moore, Cassandra N., Singh, Parminder, Sharpsten, Renee K., Costello, Brian A., Bryce, Alan H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385473/ https://www.ncbi.nlm.nih.gov/pubmed/34294873 http://dx.doi.org/10.1038/s41391-021-00430-4

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