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Immunosurveillance of Candida albicans commensalism by the adaptive immune system

The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to i...

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Autores principales: Swidergall, Marc, LeibundGut-Landmann, Salomé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385492/
https://www.ncbi.nlm.nih.gov/pubmed/35778599
http://dx.doi.org/10.1038/s41385-022-00536-5
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author Swidergall, Marc
LeibundGut-Landmann, Salomé
author_facet Swidergall, Marc
LeibundGut-Landmann, Salomé
author_sort Swidergall, Marc
collection PubMed
description The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.
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spelling pubmed-93854922022-08-19 Immunosurveillance of Candida albicans commensalism by the adaptive immune system Swidergall, Marc LeibundGut-Landmann, Salomé Mucosal Immunol Review Article The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease. Nature Publishing Group US 2022-07-01 2022 /pmc/articles/PMC9385492/ /pubmed/35778599 http://dx.doi.org/10.1038/s41385-022-00536-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Swidergall, Marc
LeibundGut-Landmann, Salomé
Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title_full Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title_fullStr Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title_full_unstemmed Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title_short Immunosurveillance of Candida albicans commensalism by the adaptive immune system
title_sort immunosurveillance of candida albicans commensalism by the adaptive immune system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385492/
https://www.ncbi.nlm.nih.gov/pubmed/35778599
http://dx.doi.org/10.1038/s41385-022-00536-5
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