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Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar

COVID-19 vaccines are generally proven safe in all population and are highly recommended. However, rare adverse events have been reported. We hereby present a case of an 18-year-old man who presented to emergency department with fever, meningitis like symptoms, shortness of breath, chest pain, skin...

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Autores principales: Varghese, Manoj, Alsoub, Hussam Abdel Rahman S., Koleri, Junais, El Ajez, Reem Hasan Mustafa, Alsehli, Ziad Mohamad, Alkailani, Yaman Ismael Gh, Al Maslamani, Muna A. Rahman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385574/
https://www.ncbi.nlm.nih.gov/pubmed/35996419
http://dx.doi.org/10.1016/j.idcr.2022.e01606
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author Varghese, Manoj
Alsoub, Hussam Abdel Rahman S.
Koleri, Junais
El Ajez, Reem Hasan Mustafa
Alsehli, Ziad Mohamad
Alkailani, Yaman Ismael Gh
Al Maslamani, Muna A. Rahman S.
author_facet Varghese, Manoj
Alsoub, Hussam Abdel Rahman S.
Koleri, Junais
El Ajez, Reem Hasan Mustafa
Alsehli, Ziad Mohamad
Alkailani, Yaman Ismael Gh
Al Maslamani, Muna A. Rahman S.
author_sort Varghese, Manoj
collection PubMed
description COVID-19 vaccines are generally proven safe in all population and are highly recommended. However, rare adverse events have been reported. We hereby present a case of an 18-year-old man who presented to emergency department with fever, meningitis like symptoms, shortness of breath, chest pain, skin rash, and extreme fatigue. He had cardiac manifestations including hypotension, elevated troponin, and reduced ejection fraction. High inflammatory markers were also noted. He was initially worked up for and treated as a possible infectious etiology, but the microbiological studies were negative and there was no response to treatment. Since he had recently received booster dose of Pfizer-BioNTech COVID-19 vaccination three weeks prior to onset of symptoms, a possibility of Multisystem inflammatory syndrome in children (MIS-C) was made. His presentation fulfilled all the diagnostic criteria. The possibility for MIS-C being related to vaccination was proposed after relevant serological tests showed that the antibodies, he had were due to COVID-19 vaccine, not to a prior infection. After he received appropriate immunomodulatory treatment (IVIG and methylprednisolone) as per the guideline, he showed marked clinical improvement. Our case report highlights the need to consider MIS-C as a potential differential in young patients who present with unexplained multisystem illness with increased inflammatory markers and negative microbiologic work-up. MIS-C can be secondary to COVID-19 vaccination as well as to prior COVID-19 infection
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spelling pubmed-93855742022-08-18 Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar Varghese, Manoj Alsoub, Hussam Abdel Rahman S. Koleri, Junais El Ajez, Reem Hasan Mustafa Alsehli, Ziad Mohamad Alkailani, Yaman Ismael Gh Al Maslamani, Muna A. Rahman S. IDCases Case Report COVID-19 vaccines are generally proven safe in all population and are highly recommended. However, rare adverse events have been reported. We hereby present a case of an 18-year-old man who presented to emergency department with fever, meningitis like symptoms, shortness of breath, chest pain, skin rash, and extreme fatigue. He had cardiac manifestations including hypotension, elevated troponin, and reduced ejection fraction. High inflammatory markers were also noted. He was initially worked up for and treated as a possible infectious etiology, but the microbiological studies were negative and there was no response to treatment. Since he had recently received booster dose of Pfizer-BioNTech COVID-19 vaccination three weeks prior to onset of symptoms, a possibility of Multisystem inflammatory syndrome in children (MIS-C) was made. His presentation fulfilled all the diagnostic criteria. The possibility for MIS-C being related to vaccination was proposed after relevant serological tests showed that the antibodies, he had were due to COVID-19 vaccine, not to a prior infection. After he received appropriate immunomodulatory treatment (IVIG and methylprednisolone) as per the guideline, he showed marked clinical improvement. Our case report highlights the need to consider MIS-C as a potential differential in young patients who present with unexplained multisystem illness with increased inflammatory markers and negative microbiologic work-up. MIS-C can be secondary to COVID-19 vaccination as well as to prior COVID-19 infection Elsevier 2022-08-18 /pmc/articles/PMC9385574/ /pubmed/35996419 http://dx.doi.org/10.1016/j.idcr.2022.e01606 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Varghese, Manoj
Alsoub, Hussam Abdel Rahman S.
Koleri, Junais
El Ajez, Reem Hasan Mustafa
Alsehli, Ziad Mohamad
Alkailani, Yaman Ismael Gh
Al Maslamani, Muna A. Rahman S.
Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title_full Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title_fullStr Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title_full_unstemmed Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title_short Multisystem inflammatory syndrome in children (MIS-C) secondary to COVID-19 mRNA vaccination – A case report from Qatar
title_sort multisystem inflammatory syndrome in children (mis-c) secondary to covid-19 mrna vaccination – a case report from qatar
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385574/
https://www.ncbi.nlm.nih.gov/pubmed/35996419
http://dx.doi.org/10.1016/j.idcr.2022.e01606
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