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Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation. Recent work has surprisingly identified CPSF73 as a promising drug target for inhibiting the growth of specific cancers, triggering further studies on understanding CPSF...

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Detalles Bibliográficos
Autores principales:	Liu, Huiyun, Heller-Trulli, Daniel, Moore, Claire L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385686/ https://www.ncbi.nlm.nih.gov/pubmed/35992060 http://dx.doi.org/10.1016/j.isci.2022.104804

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