A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer

Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often leads to dose-limiting toxicity (DLT), affecting quality of life. PRV111 is a nanotechnology-based system for local delivery of cisplatin loa...

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Detalles Bibliográficos
Autores principales: Goldberg, Manijeh, Manzi, Aaron, Birdi, Amritpreet, Laporte, Brandon, Conway, Peter, Cantin, Stefanie, Mishra, Vasudha, Singh, Alka, Pearson, Alexander T., Goldberg, Eric R., Goldberger, Sam, Flaum, Benjamin, Hasina, Rifat, London, Nyall R., Gallia, Gary L., Bettegowda, Chetan, Young, Simon, Sandulache, Vlad, Melville, James, Shum, Jonathan, O’Neill, Sonya E., Aydin, Erkin, Zhavoronkov, Alex, Vidal, Anxo, Soto, Atenea, Alonso, Maria Jose, Rosenberg, Ari J., Lingen, Mark W., D’Cruz, Anil, Agrawal, Nishant, Izumchenko, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385702/
https://www.ncbi.nlm.nih.gov/pubmed/35977936
http://dx.doi.org/10.1038/s41467-022-31859-3

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