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On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control

The dynamics of COVID-19 virus were investigated in the literature via mathematical models. These models take into account the action of the suspected-exposed-infected-recovered people (SEIR). Also, among them, those which account for quarantined, social distancing functions or health isolation, wer...

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Autores principales: Abdel-Gawad, Hamdy I., Abdel-Gawad, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385775/
http://dx.doi.org/10.1016/j.aej.2022.08.022
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author Abdel-Gawad, Hamdy I.
Abdel-Gawad, Ahmed H.
author_facet Abdel-Gawad, Hamdy I.
Abdel-Gawad, Ahmed H.
author_sort Abdel-Gawad, Hamdy I.
collection PubMed
description The dynamics of COVID-19 virus were investigated in the literature via mathematical models. These models take into account the action of the suspected-exposed-infected-recovered people (SEIR). Also, among them, those which account for quarantined, social distancing functions or health isolation, were presented. In the absence of effective vaccines or therapies, prevention and treatment strategies for COVID-19 infections can not issue to non-epidemic state. Over the world, vaccination against the virus is set on. This motivated us to develop a model for inspecting if this treatment will issue to non endemic state. To this end, a global continuum model for the dynamics of this virus in the presence of vaccine and stimulated immunity is constructed. The present model deals with EIR - deceased individuals (EIRD) together with action of the health isolation and travelers (HIT). Which is described by nonlinear dynamical system (NLDS). Our aim here is to reduce the problem of solving this system to the case of solving LDS. This is carried by introducing the unified method (UM) via an approach present by the authors. By the UM, the solutions of a NLDS are recast to solutions of LDS via auxiliary equations. Numerical results of the exact solutions are evaluated, with initial data for the EIRD together with the number of vaccinated people. Real data are taken from Egypt (can be from elsewhere) at the end of the first wave, and they are considered as the initial conditions. These results are compared with a previous work by the authors in the absence of vaccination. The results of exposed, infected, recovered and deceased people are computed. It is found that the number of infected people decays to zero asymptotically, while, the number of infected people decays to an asymptotic value. This is in contrast to the results found previously in the case of absence of vaccination, where, these numbers grow monotonically. This is completely new. It is shown that locking-down has a remarkable effect in diminishing the number of infected people. The region of initial conditions for I-E people, that guarantee non-epidemic, non-endemic states, is determined via initial states control analysis. A software tool, based on this model, for simplifying the utilization of various data of different countries is developed. It is worth to mention that, the exact solutions of nonlinear dynamical equations, found here, are novel.
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spelling pubmed-93857752022-08-18 On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control Abdel-Gawad, Hamdy I. Abdel-Gawad, Ahmed H. Alexandria Engineering Journal Article The dynamics of COVID-19 virus were investigated in the literature via mathematical models. These models take into account the action of the suspected-exposed-infected-recovered people (SEIR). Also, among them, those which account for quarantined, social distancing functions or health isolation, were presented. In the absence of effective vaccines or therapies, prevention and treatment strategies for COVID-19 infections can not issue to non-epidemic state. Over the world, vaccination against the virus is set on. This motivated us to develop a model for inspecting if this treatment will issue to non endemic state. To this end, a global continuum model for the dynamics of this virus in the presence of vaccine and stimulated immunity is constructed. The present model deals with EIR - deceased individuals (EIRD) together with action of the health isolation and travelers (HIT). Which is described by nonlinear dynamical system (NLDS). Our aim here is to reduce the problem of solving this system to the case of solving LDS. This is carried by introducing the unified method (UM) via an approach present by the authors. By the UM, the solutions of a NLDS are recast to solutions of LDS via auxiliary equations. Numerical results of the exact solutions are evaluated, with initial data for the EIRD together with the number of vaccinated people. Real data are taken from Egypt (can be from elsewhere) at the end of the first wave, and they are considered as the initial conditions. These results are compared with a previous work by the authors in the absence of vaccination. The results of exposed, infected, recovered and deceased people are computed. It is found that the number of infected people decays to zero asymptotically, while, the number of infected people decays to an asymptotic value. This is in contrast to the results found previously in the case of absence of vaccination, where, these numbers grow monotonically. This is completely new. It is shown that locking-down has a remarkable effect in diminishing the number of infected people. The region of initial conditions for I-E people, that guarantee non-epidemic, non-endemic states, is determined via initial states control analysis. A software tool, based on this model, for simplifying the utilization of various data of different countries is developed. It is worth to mention that, the exact solutions of nonlinear dynamical equations, found here, are novel. THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. 2022-11 2022-08-18 /pmc/articles/PMC9385775/ http://dx.doi.org/10.1016/j.aej.2022.08.022 Text en © 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Abdel-Gawad, Hamdy I.
Abdel-Gawad, Ahmed H.
On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title_full On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title_fullStr On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title_full_unstemmed On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title_short On a global continuum model for COVID-19 virus in the presence of vaccine and induced immunity. Stability and initial states control
title_sort on a global continuum model for covid-19 virus in the presence of vaccine and induced immunity. stability and initial states control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385775/
http://dx.doi.org/10.1016/j.aej.2022.08.022
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