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Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

PURPOSE: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at...

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Autores principales: Cangiano, Biagio, Giusti, Emanuele, Premoli, Caterina, Soranna, Davide, Vitale, Giovanni, Grottoli, Silvia, Cambria, Valeria, Mantovani, Giovanna, Mungari, Roberta, Maffei, Pietro, Dassie, Francesca, Giampietro, Antonella, Chiloiro, Sabrina, Tanda, Maria Laura, Ippolito, Silvia, Cannavò, Salvatore, Ragonese, Marta, Zambon, Antonella, Persani, Luca, Fatti, Letizia Maria, Scacchi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385810/
https://www.ncbi.nlm.nih.gov/pubmed/35779206
http://dx.doi.org/10.1007/s12020-022-03106-8
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author Cangiano, Biagio
Giusti, Emanuele
Premoli, Caterina
Soranna, Davide
Vitale, Giovanni
Grottoli, Silvia
Cambria, Valeria
Mantovani, Giovanna
Mungari, Roberta
Maffei, Pietro
Dassie, Francesca
Giampietro, Antonella
Chiloiro, Sabrina
Tanda, Maria Laura
Ippolito, Silvia
Cannavò, Salvatore
Ragonese, Marta
Zambon, Antonella
Persani, Luca
Fatti, Letizia Maria
Scacchi, Massimo
author_facet Cangiano, Biagio
Giusti, Emanuele
Premoli, Caterina
Soranna, Davide
Vitale, Giovanni
Grottoli, Silvia
Cambria, Valeria
Mantovani, Giovanna
Mungari, Roberta
Maffei, Pietro
Dassie, Francesca
Giampietro, Antonella
Chiloiro, Sabrina
Tanda, Maria Laura
Ippolito, Silvia
Cannavò, Salvatore
Ragonese, Marta
Zambon, Antonella
Persani, Luca
Fatti, Letizia Maria
Scacchi, Massimo
author_sort Cangiano, Biagio
collection PubMed
description PURPOSE: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. METHODS: One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression). RESULTS: A very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL. CONCLUSIONS: We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment.
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spelling pubmed-93858102022-08-19 Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life Cangiano, Biagio Giusti, Emanuele Premoli, Caterina Soranna, Davide Vitale, Giovanni Grottoli, Silvia Cambria, Valeria Mantovani, Giovanna Mungari, Roberta Maffei, Pietro Dassie, Francesca Giampietro, Antonella Chiloiro, Sabrina Tanda, Maria Laura Ippolito, Silvia Cannavò, Salvatore Ragonese, Marta Zambon, Antonella Persani, Luca Fatti, Letizia Maria Scacchi, Massimo Endocrine Original Article PURPOSE: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. METHODS: One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression). RESULTS: A very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL. CONCLUSIONS: We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment. Springer US 2022-07-02 2022 /pmc/articles/PMC9385810/ /pubmed/35779206 http://dx.doi.org/10.1007/s12020-022-03106-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Cangiano, Biagio
Giusti, Emanuele
Premoli, Caterina
Soranna, Davide
Vitale, Giovanni
Grottoli, Silvia
Cambria, Valeria
Mantovani, Giovanna
Mungari, Roberta
Maffei, Pietro
Dassie, Francesca
Giampietro, Antonella
Chiloiro, Sabrina
Tanda, Maria Laura
Ippolito, Silvia
Cannavò, Salvatore
Ragonese, Marta
Zambon, Antonella
Persani, Luca
Fatti, Letizia Maria
Scacchi, Massimo
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title_full Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title_fullStr Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title_full_unstemmed Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title_short Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
title_sort psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385810/
https://www.ncbi.nlm.nih.gov/pubmed/35779206
http://dx.doi.org/10.1007/s12020-022-03106-8
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