AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1

The mechanistic target of rapamycin (mTOR) signals through the mTOR complex 1 (mTORC1) and the mTOR complex 2 to maintain cellular and organismal homeostasis. Failure to finely tune mTOR activity results in metabolic dysregulation and disease. While there is substantial understanding of the molecula...

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Detalles Bibliográficos
Autores principales: Umanah, George K. E., Abalde-Atristain, Leire, Khan, Mohammed Repon, Mitra, Jaba, Dar, Mohamad Aasif, Chang, Melissa, Tangella, Kavya, McNamara, Amy, Bennett, Samuel, Chen, Rong, Aggarwal, Vasudha, Cortes, Marisol, Worley, Paul F., Ha, Taekjip, Dawson, Ted M., Dawson, Valina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385847/
https://www.ncbi.nlm.nih.gov/pubmed/35977929
http://dx.doi.org/10.1038/s41467-022-32365-2

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