CX-5461 causes nucleolar compaction, alteration of peri- and intranucleolar chromatin arrangement, an increase in both heterochromatin and DNA damage response

In this study, we characterize the changes in nucleolar morphology and its dynamics induced by the recently introduced compound CX-5461, an inhibitor of ribosome synthesis. Time-lapse imaging, immunofluorescence and ultrastructural analysis revealed that exposure of cells to CX-5461 has a profound i...

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Detalles Bibliográficos
Autores principales: Snyers, Luc, Laffer, Sylvia, Löhnert, Renate, Weipoltshammer, Klara, Schöfer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385865/
https://www.ncbi.nlm.nih.gov/pubmed/35978024
http://dx.doi.org/10.1038/s41598-022-17923-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385865/
https://www.ncbi.nlm.nih.gov/pubmed/35978024
http://dx.doi.org/10.1038/s41598-022-17923-4

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