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Amelioration of radiation-induced liver damage by p-coumaric acid in mice
Radiation-induced liver damage (RILD) is a spiny problem in radiotherapy or other circumstances that exposure to radiation. The need for radioprotective agent is increasing to protect liver tissue. This study aimed to explore the hepatoprotective effect of p-coumaric acid (CA) against RILD. C57BL/6...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385927/ https://www.ncbi.nlm.nih.gov/pubmed/35992325 http://dx.doi.org/10.1007/s10068-022-01118-8 |
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author | Li, Yun-Hong Wu, Jiang-Xue He, Qian Gu, Jia Zhang, Lin Niu, Hao-Zhi Zhang, Xin-Wen Zhao, Han-Ting Xu, Jia-Ying Qin, Li-Qiang |
author_facet | Li, Yun-Hong Wu, Jiang-Xue He, Qian Gu, Jia Zhang, Lin Niu, Hao-Zhi Zhang, Xin-Wen Zhao, Han-Ting Xu, Jia-Ying Qin, Li-Qiang |
author_sort | Li, Yun-Hong |
collection | PubMed |
description | Radiation-induced liver damage (RILD) is a spiny problem in radiotherapy or other circumstances that exposure to radiation. The need for radioprotective agent is increasing to protect liver tissue. This study aimed to explore the hepatoprotective effect of p-coumaric acid (CA) against RILD. C57BL/6 male mice were exposed to 4 Gy irradiation and administrated with CA for 4 days starting on the same day of irradiation. Mice were sacrificed to obtain blood and liver tissues on day 3.5 or 14 post irradiation, respectively. The blood and liver tissues were collected. As compared with the only irradiated group, CA supplementation improved liver morphology, decreased serum alanine aminotransferase and aspartate aminotransferase, inhibited BCL2-associated X (BAX) protein expression, and improved the mice hematopoietic function. CA at the dose of 100 mg/kg body weight showed better effect compared to the other doses. Thus, CA might possess potential to protect against RILD. |
format | Online Article Text |
id | pubmed-9385927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-93859272022-08-19 Amelioration of radiation-induced liver damage by p-coumaric acid in mice Li, Yun-Hong Wu, Jiang-Xue He, Qian Gu, Jia Zhang, Lin Niu, Hao-Zhi Zhang, Xin-Wen Zhao, Han-Ting Xu, Jia-Ying Qin, Li-Qiang Food Sci Biotechnol Research Article Radiation-induced liver damage (RILD) is a spiny problem in radiotherapy or other circumstances that exposure to radiation. The need for radioprotective agent is increasing to protect liver tissue. This study aimed to explore the hepatoprotective effect of p-coumaric acid (CA) against RILD. C57BL/6 male mice were exposed to 4 Gy irradiation and administrated with CA for 4 days starting on the same day of irradiation. Mice were sacrificed to obtain blood and liver tissues on day 3.5 or 14 post irradiation, respectively. The blood and liver tissues were collected. As compared with the only irradiated group, CA supplementation improved liver morphology, decreased serum alanine aminotransferase and aspartate aminotransferase, inhibited BCL2-associated X (BAX) protein expression, and improved the mice hematopoietic function. CA at the dose of 100 mg/kg body weight showed better effect compared to the other doses. Thus, CA might possess potential to protect against RILD. Springer Nature Singapore 2022-06-15 /pmc/articles/PMC9385927/ /pubmed/35992325 http://dx.doi.org/10.1007/s10068-022-01118-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Li, Yun-Hong Wu, Jiang-Xue He, Qian Gu, Jia Zhang, Lin Niu, Hao-Zhi Zhang, Xin-Wen Zhao, Han-Ting Xu, Jia-Ying Qin, Li-Qiang Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title | Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title_full | Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title_fullStr | Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title_full_unstemmed | Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title_short | Amelioration of radiation-induced liver damage by p-coumaric acid in mice |
title_sort | amelioration of radiation-induced liver damage by p-coumaric acid in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385927/ https://www.ncbi.nlm.nih.gov/pubmed/35992325 http://dx.doi.org/10.1007/s10068-022-01118-8 |
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