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Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications
Flexible and context-appropriate social functioning is key for survival across species. This flexibility also renders social behavior highly plastic, particularly during early development when attachment to caregiver can provide a template for future social processing. As a result, early caregiving...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385963/ https://www.ncbi.nlm.nih.gov/pubmed/35990728 http://dx.doi.org/10.3389/fnbeh.2022.918862 |
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author | Packard, Katherine Opendak, Maya |
author_facet | Packard, Katherine Opendak, Maya |
author_sort | Packard, Katherine |
collection | PubMed |
description | Flexible and context-appropriate social functioning is key for survival across species. This flexibility also renders social behavior highly plastic, particularly during early development when attachment to caregiver can provide a template for future social processing. As a result, early caregiving adversity can have unique and lasting impacts on social behavior and even confer vulnerability to psychiatric disorders. However, the neural circuit mechanisms translating experience to outcome remain poorly understood. Here, we consider social behavior scaffolding through the lens of reward and threat processing. We begin by surveying several complementary rodent models of early adversity, which together have highlighted impacts on neural circuits processing social cues. We next explore these circuits underlying perturbed social functioning with focus on dopamine (DA) and its role in regions implicated in social and threat processing such as the prefrontal cortex (PFC), basolateral amygdala (BLA) and the lateral habenula (LHb). Finally, we turn to human populations once more to examine how altered DA signaling and LHb dysfunction may play a role in social anhedonia, a common feature in diagnoses such as schizophrenia and major depressive disorder (MDD). We argue that this translational focus is critical for identifying specific features of adversity that confer heightened vulnerability for clinical outcomes involving social cue processing. |
format | Online Article Text |
id | pubmed-9385963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93859632022-08-19 Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications Packard, Katherine Opendak, Maya Front Behav Neurosci Behavioral Neuroscience Flexible and context-appropriate social functioning is key for survival across species. This flexibility also renders social behavior highly plastic, particularly during early development when attachment to caregiver can provide a template for future social processing. As a result, early caregiving adversity can have unique and lasting impacts on social behavior and even confer vulnerability to psychiatric disorders. However, the neural circuit mechanisms translating experience to outcome remain poorly understood. Here, we consider social behavior scaffolding through the lens of reward and threat processing. We begin by surveying several complementary rodent models of early adversity, which together have highlighted impacts on neural circuits processing social cues. We next explore these circuits underlying perturbed social functioning with focus on dopamine (DA) and its role in regions implicated in social and threat processing such as the prefrontal cortex (PFC), basolateral amygdala (BLA) and the lateral habenula (LHb). Finally, we turn to human populations once more to examine how altered DA signaling and LHb dysfunction may play a role in social anhedonia, a common feature in diagnoses such as schizophrenia and major depressive disorder (MDD). We argue that this translational focus is critical for identifying specific features of adversity that confer heightened vulnerability for clinical outcomes involving social cue processing. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9385963/ /pubmed/35990728 http://dx.doi.org/10.3389/fnbeh.2022.918862 Text en Copyright © 2022 Packard and Opendak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Packard, Katherine Opendak, Maya Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title | Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title_full | Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title_fullStr | Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title_full_unstemmed | Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title_short | Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications |
title_sort | rodent models of early adversity: impacts on developing social behavior circuitry and clinical implications |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385963/ https://www.ncbi.nlm.nih.gov/pubmed/35990728 http://dx.doi.org/10.3389/fnbeh.2022.918862 |
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