Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype

Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like phenotype supportive of tumor growth, immune evasion, and metastasis. IL-4 and IL-13 are major cytokines that polarize macrophages to an M2 subset...

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Detalles Bibliográficos
Autores principales: de Groot, Amber E., Myers, Kayla V., Krueger, Timothy E.G., Brennen, W. Nathaniel, Amend, Sarah R., Pienta, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386102/
https://www.ncbi.nlm.nih.gov/pubmed/35939881
http://dx.doi.org/10.1016/j.neo.2022.100830

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