A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis

Trimethoprim-Sulfamethoxazole is a commonly used antibiotic for treatment of urinary tract infections, but also used to treat less common conditions such as pulmonary nocardiosis. N4-acetyl-sulfamethoxazole is the main active metabolite of Sulfamethoxazole. Pure stones of this compound are very rare...

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Autores principales: Shanholtzer, Andrew, Geisenhoff, Alexander, Shah, Mit, Shetty, Sugandh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Endourology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386110/
https://www.ncbi.nlm.nih.gov/pubmed/35991217
http://dx.doi.org/10.1016/j.eucr.2022.102179
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author Shanholtzer, Andrew
Geisenhoff, Alexander
Shah, Mit
Shetty, Sugandh
author_facet Shanholtzer, Andrew
Geisenhoff, Alexander
Shah, Mit
Shetty, Sugandh
author_sort Shanholtzer, Andrew
collection PubMed
description Trimethoprim-Sulfamethoxazole is a commonly used antibiotic for treatment of urinary tract infections, but also used to treat less common conditions such as pulmonary nocardiosis. N4-acetyl-sulfamethoxazole is the main active metabolite of Sulfamethoxazole. Pure stones of this compound are very rare with only a few cases documented in the literature. Here we present a case of a patient treated with long term trimethoprim-sulfamethoxazole therapy for pulmonary nocardiosis who developed pure N4-acetyl-sulfamethoxazole nephrolithiasis resulting in upper tract obstruction. This report provides an additional data point for this unique calculus etiology.
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spelling pubmed-93861102022-08-19 A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis Shanholtzer, Andrew Geisenhoff, Alexander Shah, Mit Shetty, Sugandh Urol Case Rep Endourology Trimethoprim-Sulfamethoxazole is a commonly used antibiotic for treatment of urinary tract infections, but also used to treat less common conditions such as pulmonary nocardiosis. N4-acetyl-sulfamethoxazole is the main active metabolite of Sulfamethoxazole. Pure stones of this compound are very rare with only a few cases documented in the literature. Here we present a case of a patient treated with long term trimethoprim-sulfamethoxazole therapy for pulmonary nocardiosis who developed pure N4-acetyl-sulfamethoxazole nephrolithiasis resulting in upper tract obstruction. This report provides an additional data point for this unique calculus etiology. Elsevier 2022-08-03 /pmc/articles/PMC9386110/ /pubmed/35991217 http://dx.doi.org/10.1016/j.eucr.2022.102179 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Endourology
Shanholtzer, Andrew
Geisenhoff, Alexander
Shah, Mit
Shetty, Sugandh
A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title_full A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title_fullStr A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title_full_unstemmed A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title_short A rare case of pure N4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
title_sort rare case of pure n4-acetyl-sulfamethoxazole nephrolithiasis associated with trimethoprim-sulfamethoxazole treatment of pulmonary nocardiosis
topic Endourology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386110/
https://www.ncbi.nlm.nih.gov/pubmed/35991217
http://dx.doi.org/10.1016/j.eucr.2022.102179
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