NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury

In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression leads to the disruption of the pulmonary endothelial barrier. Previous studies have suggested that the action of NF-κB as a transcriptional repressor also requires the action of class I histone deacetylases (HDACs...

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Detalles Bibliográficos
Autores principales: Zemskov, Evgeny A., Gross, Christine M., Aggarwal, Saurabh, Zemskova, Marina A., Wu, Xiaomin, Gu, Chenxin, Wang, Ting, Tang, Haiyang, Black, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386230/
https://www.ncbi.nlm.nih.gov/pubmed/35991176
http://dx.doi.org/10.3389/fphys.2022.947537

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