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Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wa...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386258/ https://www.ncbi.nlm.nih.gov/pubmed/35990352 http://dx.doi.org/10.3389/fnut.2022.978475 |
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author | Fu, Chenghao Li, Yuemin Xi, Hao Niu, Zemiao Chen, Ning Wang, Rong Yan, Yonghuan Gan, Xiaoruo Wang, Mengtian Zhang, Wei Zhang, Yan Lv, Pin |
author_facet | Fu, Chenghao Li, Yuemin Xi, Hao Niu, Zemiao Chen, Ning Wang, Rong Yan, Yonghuan Gan, Xiaoruo Wang, Mengtian Zhang, Wei Zhang, Yan Lv, Pin |
author_sort | Fu, Chenghao |
collection | PubMed |
description | Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways. |
format | Online Article Text |
id | pubmed-9386258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93862582022-08-19 Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism Fu, Chenghao Li, Yuemin Xi, Hao Niu, Zemiao Chen, Ning Wang, Rong Yan, Yonghuan Gan, Xiaoruo Wang, Mengtian Zhang, Wei Zhang, Yan Lv, Pin Front Nutr Nutrition Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9386258/ /pubmed/35990352 http://dx.doi.org/10.3389/fnut.2022.978475 Text en Copyright © 2022 Fu, Li, Xi, Niu, Chen, Wang, Yan, Gan, Wang, Zhang, Zhang and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Fu, Chenghao Li, Yuemin Xi, Hao Niu, Zemiao Chen, Ning Wang, Rong Yan, Yonghuan Gan, Xiaoruo Wang, Mengtian Zhang, Wei Zhang, Yan Lv, Pin Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title | Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title_full | Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title_fullStr | Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title_full_unstemmed | Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title_short | Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism |
title_sort | benzo(a)pyrene and cardiovascular diseases: an overview of pre-clinical studies focused on the underlying molecular mechanism |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386258/ https://www.ncbi.nlm.nih.gov/pubmed/35990352 http://dx.doi.org/10.3389/fnut.2022.978475 |
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