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Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wa...

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Autores principales: Fu, Chenghao, Li, Yuemin, Xi, Hao, Niu, Zemiao, Chen, Ning, Wang, Rong, Yan, Yonghuan, Gan, Xiaoruo, Wang, Mengtian, Zhang, Wei, Zhang, Yan, Lv, Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386258/
https://www.ncbi.nlm.nih.gov/pubmed/35990352
http://dx.doi.org/10.3389/fnut.2022.978475
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author Fu, Chenghao
Li, Yuemin
Xi, Hao
Niu, Zemiao
Chen, Ning
Wang, Rong
Yan, Yonghuan
Gan, Xiaoruo
Wang, Mengtian
Zhang, Wei
Zhang, Yan
Lv, Pin
author_facet Fu, Chenghao
Li, Yuemin
Xi, Hao
Niu, Zemiao
Chen, Ning
Wang, Rong
Yan, Yonghuan
Gan, Xiaoruo
Wang, Mengtian
Zhang, Wei
Zhang, Yan
Lv, Pin
author_sort Fu, Chenghao
collection PubMed
description Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways.
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spelling pubmed-93862582022-08-19 Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism Fu, Chenghao Li, Yuemin Xi, Hao Niu, Zemiao Chen, Ning Wang, Rong Yan, Yonghuan Gan, Xiaoruo Wang, Mengtian Zhang, Wei Zhang, Yan Lv, Pin Front Nutr Nutrition Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9386258/ /pubmed/35990352 http://dx.doi.org/10.3389/fnut.2022.978475 Text en Copyright © 2022 Fu, Li, Xi, Niu, Chen, Wang, Yan, Gan, Wang, Zhang, Zhang and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Fu, Chenghao
Li, Yuemin
Xi, Hao
Niu, Zemiao
Chen, Ning
Wang, Rong
Yan, Yonghuan
Gan, Xiaoruo
Wang, Mengtian
Zhang, Wei
Zhang, Yan
Lv, Pin
Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title_full Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title_fullStr Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title_full_unstemmed Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title_short Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism
title_sort benzo(a)pyrene and cardiovascular diseases: an overview of pre-clinical studies focused on the underlying molecular mechanism
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386258/
https://www.ncbi.nlm.nih.gov/pubmed/35990352
http://dx.doi.org/10.3389/fnut.2022.978475
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