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Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review
Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension caused by chronic venous thromboembolism (VTE). Venous thromboembolism (VTE) manifests as deep vein thrombosis (DVT), progressing to pulmonary embolism (PE). Pulmonary endarterectomy (PEA) is the preferred ther...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386320/ https://www.ncbi.nlm.nih.gov/pubmed/35989750 http://dx.doi.org/10.7759/cureus.27007 |
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author | Dolkar, Tsering Chaudry, Aysham Salauddin, Ferdous Nway, Nway Kadakia, Nevil Kalavar, Madhumati Dogar, Muhammad H |
author_facet | Dolkar, Tsering Chaudry, Aysham Salauddin, Ferdous Nway, Nway Kadakia, Nevil Kalavar, Madhumati Dogar, Muhammad H |
author_sort | Dolkar, Tsering |
collection | PubMed |
description | Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension caused by chronic venous thromboembolism (VTE). Venous thromboembolism (VTE) manifests as deep vein thrombosis (DVT), progressing to pulmonary embolism (PE). Pulmonary endarterectomy (PEA) is the preferred therapeutic option as it provides vascular disobliteration. Long-term anticoagulation with warfarin or direct oral anticoagulants (DOACs) is recommended for patients at risk for recurrent DVT in poor surgical candidates. However, treatment failure remains a concern. We present a patient who had VTE despite long-term anticoagulation with warfarin who had failed treatment and developed VTE with a therapeutic dilemma to continue anticoagulation despite supratherapeutic international normalized ratio (INR). |
format | Online Article Text |
id | pubmed-9386320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-93863202022-08-20 Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review Dolkar, Tsering Chaudry, Aysham Salauddin, Ferdous Nway, Nway Kadakia, Nevil Kalavar, Madhumati Dogar, Muhammad H Cureus Internal Medicine Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension caused by chronic venous thromboembolism (VTE). Venous thromboembolism (VTE) manifests as deep vein thrombosis (DVT), progressing to pulmonary embolism (PE). Pulmonary endarterectomy (PEA) is the preferred therapeutic option as it provides vascular disobliteration. Long-term anticoagulation with warfarin or direct oral anticoagulants (DOACs) is recommended for patients at risk for recurrent DVT in poor surgical candidates. However, treatment failure remains a concern. We present a patient who had VTE despite long-term anticoagulation with warfarin who had failed treatment and developed VTE with a therapeutic dilemma to continue anticoagulation despite supratherapeutic international normalized ratio (INR). Cureus 2022-07-19 /pmc/articles/PMC9386320/ /pubmed/35989750 http://dx.doi.org/10.7759/cureus.27007 Text en Copyright © 2022, Dolkar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Dolkar, Tsering Chaudry, Aysham Salauddin, Ferdous Nway, Nway Kadakia, Nevil Kalavar, Madhumati Dogar, Muhammad H Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title | Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title_full | Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title_fullStr | Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title_full_unstemmed | Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title_short | Warfarin Failure in a Patient With Chronic Thromboembolic Pulmonary Hypertension: A Case Report and Literature Review |
title_sort | warfarin failure in a patient with chronic thromboembolic pulmonary hypertension: a case report and literature review |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386320/ https://www.ncbi.nlm.nih.gov/pubmed/35989750 http://dx.doi.org/10.7759/cureus.27007 |
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