Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia

Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personal...

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Autores principales: Song, Yang, Fang, Qiuyun, Mi, Yingchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386345/
https://www.ncbi.nlm.nih.gov/pubmed/35992882
http://dx.doi.org/10.3389/fonc.2022.981036
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author Song, Yang
Fang, Qiuyun
Mi, Yingchang
author_facet Song, Yang
Fang, Qiuyun
Mi, Yingchang
author_sort Song, Yang
collection PubMed
description Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.
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spelling pubmed-93863452022-08-19 Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia Song, Yang Fang, Qiuyun Mi, Yingchang Front Oncol Oncology Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9386345/ /pubmed/35992882 http://dx.doi.org/10.3389/fonc.2022.981036 Text en Copyright © 2022 Song, Fang and Mi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Song, Yang
Fang, Qiuyun
Mi, Yingchang
Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title_full Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title_fullStr Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title_full_unstemmed Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title_short Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia
title_sort prognostic significance of copy number variation in b-cell acute lymphoblastic leukemia
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386345/
https://www.ncbi.nlm.nih.gov/pubmed/35992882
http://dx.doi.org/10.3389/fonc.2022.981036
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