Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis

BACKGROUND: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients. SUMMARY: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultim...

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Detalles Bibliográficos
Autores principales: Xie, Zuoquan, Tong, Siyu, Chu, Xingkun, Feng, Teng, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386403/
https://www.ncbi.nlm.nih.gov/pubmed/36157262
http://dx.doi.org/10.1159/000524475
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author Xie, Zuoquan
Tong, Siyu
Chu, Xingkun
Feng, Teng
Geng, Meiyu
author_facet Xie, Zuoquan
Tong, Siyu
Chu, Xingkun
Feng, Teng
Geng, Meiyu
author_sort Xie, Zuoquan
collection PubMed
description BACKGROUND: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients. SUMMARY: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment is important for early diagnosis and prevention, which undoubtedly prompts innovative pharmacological treatments. KEY MESSAGES: Here, we sequentially review the current understanding and advances in the epidemiology, risk factors, and pathological mechanisms of cognitive impairment in CKD. Furthermore, we summarize the currently available therapeutic strategies for cognitive impairment in CKD.
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spelling pubmed-93864032022-09-23 Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis Xie, Zuoquan Tong, Siyu Chu, Xingkun Feng, Teng Geng, Meiyu Kidney Dis (Basel) Review Article BACKGROUND: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients. SUMMARY: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment is important for early diagnosis and prevention, which undoubtedly prompts innovative pharmacological treatments. KEY MESSAGES: Here, we sequentially review the current understanding and advances in the epidemiology, risk factors, and pathological mechanisms of cognitive impairment in CKD. Furthermore, we summarize the currently available therapeutic strategies for cognitive impairment in CKD. S. Karger AG 2022-05-03 /pmc/articles/PMC9386403/ /pubmed/36157262 http://dx.doi.org/10.1159/000524475 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Review Article
Xie, Zuoquan
Tong, Siyu
Chu, Xingkun
Feng, Teng
Geng, Meiyu
Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title_full Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title_fullStr Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title_full_unstemmed Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title_short Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
title_sort chronic kidney disease and cognitive impairment: the kidney-brain axis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386403/
https://www.ncbi.nlm.nih.gov/pubmed/36157262
http://dx.doi.org/10.1159/000524475
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