Cargando…

Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study

BACKGROUND: Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are c...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuo, Chengui, Zhao, Jianqiang, Wang, Qiqi, Lin, Zujin, Cai, Haipeng, Pan, Huili, Chen, Lei, Jin, Xiangyu, Jin, Hong, Xu, Longwei, Tao, Xiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386423/
https://www.ncbi.nlm.nih.gov/pubmed/35990959
http://dx.doi.org/10.3389/fcvm.2022.930077
_version_ 1784769807188492288
author Zhuo, Chengui
Zhao, Jianqiang
Wang, Qiqi
Lin, Zujin
Cai, Haipeng
Pan, Huili
Chen, Lei
Jin, Xiangyu
Jin, Hong
Xu, Longwei
Tao, Xiyan
author_facet Zhuo, Chengui
Zhao, Jianqiang
Wang, Qiqi
Lin, Zujin
Cai, Haipeng
Pan, Huili
Chen, Lei
Jin, Xiangyu
Jin, Hong
Xu, Longwei
Tao, Xiyan
author_sort Zhuo, Chengui
collection PubMed
description BACKGROUND: Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated. METHODS: We identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold (P < 5 × 10(−8)) from UK Biobank participants and evaluated these in relation to risk of CVDs. MR estimates was calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analysis was further conducted. RESULTS: Genetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950–0.984; p = 0.000222), however, suggestive significance was found between left-hand grip strength and atrial fibrillation (OR, 0.977; 95% CI, 0.957–0.998; p = 0.033). Results were similar in several sensitivity analysis. CONCLUSION: Our study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures.
format Online
Article
Text
id pubmed-9386423
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93864232022-08-19 Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study Zhuo, Chengui Zhao, Jianqiang Wang, Qiqi Lin, Zujin Cai, Haipeng Pan, Huili Chen, Lei Jin, Xiangyu Jin, Hong Xu, Longwei Tao, Xiyan Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated. METHODS: We identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold (P < 5 × 10(−8)) from UK Biobank participants and evaluated these in relation to risk of CVDs. MR estimates was calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analysis was further conducted. RESULTS: Genetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950–0.984; p = 0.000222), however, suggestive significance was found between left-hand grip strength and atrial fibrillation (OR, 0.977; 95% CI, 0.957–0.998; p = 0.033). Results were similar in several sensitivity analysis. CONCLUSION: Our study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9386423/ /pubmed/35990959 http://dx.doi.org/10.3389/fcvm.2022.930077 Text en Copyright © 2022 Zhuo, Zhao, Wang, Lin, Cai, Pan, Chen, Jin, Jin, Xu and Tao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhuo, Chengui
Zhao, Jianqiang
Wang, Qiqi
Lin, Zujin
Cai, Haipeng
Pan, Huili
Chen, Lei
Jin, Xiangyu
Jin, Hong
Xu, Longwei
Tao, Xiyan
Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title_full Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title_fullStr Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title_full_unstemmed Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title_short Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
title_sort assessment of causal associations between handgrip strength and cardiovascular diseases: a two sample mendelian randomization study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386423/
https://www.ncbi.nlm.nih.gov/pubmed/35990959
http://dx.doi.org/10.3389/fcvm.2022.930077
work_keys_str_mv AT zhuochengui assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT zhaojianqiang assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT wangqiqi assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT linzujin assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT caihaipeng assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT panhuili assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT chenlei assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT jinxiangyu assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT jinhong assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT xulongwei assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy
AT taoxiyan assessmentofcausalassociationsbetweenhandgripstrengthandcardiovasculardiseasesatwosamplemendelianrandomizationstudy