Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report

TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory case...

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Autores principales: Zeller, Felix K., Bader, Patrick R., Nägeli, Mirjam C., Buehler, Philipp K., Schuepbach, Reto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386431/
https://www.ncbi.nlm.nih.gov/pubmed/36158858
http://dx.doi.org/10.1159/000525752
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author Zeller, Felix K.
Bader, Patrick R.
Nägeli, Mirjam C.
Buehler, Philipp K.
Schuepbach, Reto A.
author_facet Zeller, Felix K.
Bader, Patrick R.
Nägeli, Mirjam C.
Buehler, Philipp K.
Schuepbach, Reto A.
author_sort Zeller, Felix K.
collection PubMed
description TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory cases, is benralizumab as an IL-5-receptor alpha-chain-specific humanized monoclonal antibody (IgG1k). We are able to show a successful treatment in this case report.
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spelling pubmed-93864312022-09-23 Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report Zeller, Felix K. Bader, Patrick R. Nägeli, Mirjam C. Buehler, Philipp K. Schuepbach, Reto A. Case Rep Dermatol Single Case TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory cases, is benralizumab as an IL-5-receptor alpha-chain-specific humanized monoclonal antibody (IgG1k). We are able to show a successful treatment in this case report. S. Karger AG 2022-07-14 /pmc/articles/PMC9386431/ /pubmed/36158858 http://dx.doi.org/10.1159/000525752 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Zeller, Felix K.
Bader, Patrick R.
Nägeli, Mirjam C.
Buehler, Philipp K.
Schuepbach, Reto A.
Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title_full Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title_fullStr Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title_full_unstemmed Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title_short Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report
title_sort severe toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms overlap syndrome treated with benralizumab: a case report
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386431/
https://www.ncbi.nlm.nih.gov/pubmed/36158858
http://dx.doi.org/10.1159/000525752
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