Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases

Antibiotic resistance via epigenetic methylation of ribosomal RNA is one of the most prevalent strategies adopted by multidrug resistant pathogens. The erythromycin-resistance methyltransferase (Erm) methylates rRNA at the conserved A2058 position and imparts resistance to macrolides such as erythro...

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Detalles Bibliográficos
Autores principales: Bhujbalrao, Ruchika, Gavvala, Krishna, Singh, Reman Kumar, Singh, Juhi, Boudier, Christian, Chakrabarti, Sutapa, Patwari, G. Naresh, Mély, Yves, Anand, Ruchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386465/
https://www.ncbi.nlm.nih.gov/pubmed/35772496
http://dx.doi.org/10.1016/j.jbc.2022.102208

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