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Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()

Triple-negative breast cancer (TNBC) patients are considered intractable, as this disease has few effective treatments and a very poor prognosis even in its early stages. Here, intratumoral therapy with resveratrol (Res), which has anticancer and metastasis inhibitory effects, was proposed for the e...

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Autores principales: Shin, Gi Ru, Kim, Hee Eun, Ju, Hyeon Jin, Kim, Jae Ho, Choi, Sangdun, Choi, Hak Soo, Kim, Moon Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386493/
https://www.ncbi.nlm.nih.gov/pubmed/35991627
http://dx.doi.org/10.1016/j.mtbio.2022.100386
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author Shin, Gi Ru
Kim, Hee Eun
Ju, Hyeon Jin
Kim, Jae Ho
Choi, Sangdun
Choi, Hak Soo
Kim, Moon Suk
author_facet Shin, Gi Ru
Kim, Hee Eun
Ju, Hyeon Jin
Kim, Jae Ho
Choi, Sangdun
Choi, Hak Soo
Kim, Moon Suk
author_sort Shin, Gi Ru
collection PubMed
description Triple-negative breast cancer (TNBC) patients are considered intractable, as this disease has few effective treatments and a very poor prognosis even in its early stages. Here, intratumoral therapy with resveratrol (Res), which has anticancer and metastasis inhibitory effects, was proposed for the effective treatment of TNBC. An injectable Res-loaded click-crosslinked hyaluronic acid (Res-Cx-HA) hydrogel was designed and intratumorally injected to generate a Res-Cx-HA depot inside the tumor. The Res-Cx-HA formulation exhibited good injectability into the tumor tissue, quick depot formation inside the tumor, and the depot remained inside the injected tumor for extended periods. In vivo formed Res-Cx-HA depots sustained Res inside the tumor for extended periods. More importantly, the bioavailability and therapeutic efficacy of Res remained almost exclusively within the tumor and not in other organs. Intratumoral injection of Res-Cx-HA in animal models resulted in significant negative tumor growth rates (i.e., the tumor volume decreased over time) coupled with large apoptotic cells and limited angiogenesis in tumors. Therefore, Res-Cx-HA intratumoral injection is a promising way to treat TNBC patients with high efficacy and minimal adverse effects.
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spelling pubmed-93864932022-08-19 Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer() Shin, Gi Ru Kim, Hee Eun Ju, Hyeon Jin Kim, Jae Ho Choi, Sangdun Choi, Hak Soo Kim, Moon Suk Mater Today Bio Full Length Article Triple-negative breast cancer (TNBC) patients are considered intractable, as this disease has few effective treatments and a very poor prognosis even in its early stages. Here, intratumoral therapy with resveratrol (Res), which has anticancer and metastasis inhibitory effects, was proposed for the effective treatment of TNBC. An injectable Res-loaded click-crosslinked hyaluronic acid (Res-Cx-HA) hydrogel was designed and intratumorally injected to generate a Res-Cx-HA depot inside the tumor. The Res-Cx-HA formulation exhibited good injectability into the tumor tissue, quick depot formation inside the tumor, and the depot remained inside the injected tumor for extended periods. In vivo formed Res-Cx-HA depots sustained Res inside the tumor for extended periods. More importantly, the bioavailability and therapeutic efficacy of Res remained almost exclusively within the tumor and not in other organs. Intratumoral injection of Res-Cx-HA in animal models resulted in significant negative tumor growth rates (i.e., the tumor volume decreased over time) coupled with large apoptotic cells and limited angiogenesis in tumors. Therefore, Res-Cx-HA intratumoral injection is a promising way to treat TNBC patients with high efficacy and minimal adverse effects. Elsevier 2022-08-05 /pmc/articles/PMC9386493/ /pubmed/35991627 http://dx.doi.org/10.1016/j.mtbio.2022.100386 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Full Length Article
Shin, Gi Ru
Kim, Hee Eun
Ju, Hyeon Jin
Kim, Jae Ho
Choi, Sangdun
Choi, Hak Soo
Kim, Moon Suk
Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title_full Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title_fullStr Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title_full_unstemmed Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title_short Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
title_sort injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer()
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386493/
https://www.ncbi.nlm.nih.gov/pubmed/35991627
http://dx.doi.org/10.1016/j.mtbio.2022.100386
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