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Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases

Inflammatory bowel diseases (IBDs) represent a group of chronic inflammatory disorders of the gastrointestinal (GI) tract including ulcerative colitis (UC), Crohn’s disease (CD), and unclassified IBDs. The pathogenesis of IBDs is related to genetic susceptibility, environmental factors, and dysbiosi...

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Autores principales: Che, Zhengping, Ye, Ziyu, Zhang, Xueying, Lin, Bihua, Yang, Weiqing, Liang, Yanfang, Zeng, Jincheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386516/
https://www.ncbi.nlm.nih.gov/pubmed/35990688
http://dx.doi.org/10.3389/fimmu.2022.952071
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author Che, Zhengping
Ye, Ziyu
Zhang, Xueying
Lin, Bihua
Yang, Weiqing
Liang, Yanfang
Zeng, Jincheng
author_facet Che, Zhengping
Ye, Ziyu
Zhang, Xueying
Lin, Bihua
Yang, Weiqing
Liang, Yanfang
Zeng, Jincheng
author_sort Che, Zhengping
collection PubMed
description Inflammatory bowel diseases (IBDs) represent a group of chronic inflammatory disorders of the gastrointestinal (GI) tract including ulcerative colitis (UC), Crohn’s disease (CD), and unclassified IBDs. The pathogenesis of IBDs is related to genetic susceptibility, environmental factors, and dysbiosis that can lead to the dysfunction of immune responses and dysregulated homeostasis of local mucosal tissues characterized by severe inflammatory responses and tissue damage in GI tract. To date, extensive studies have indicated that IBDs cannot be completely cured and easy to relapse, thus prompting researchers to find novel and more effective therapeutics for this disease. Due to their potent multipotent differentiation and immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs) not only play an important role in regulating immune and tissue homeostasis but also display potent therapeutic effects on various inflammatory diseases, including IBDs, in both preclinical and clinical studies. In this review, we present a comprehensive overview on the pathological mechanisms, the currently available therapeutics, particularly, the potential application of MSCs-based regenerative therapy for IBDs.
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spelling pubmed-93865162022-08-19 Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases Che, Zhengping Ye, Ziyu Zhang, Xueying Lin, Bihua Yang, Weiqing Liang, Yanfang Zeng, Jincheng Front Immunol Immunology Inflammatory bowel diseases (IBDs) represent a group of chronic inflammatory disorders of the gastrointestinal (GI) tract including ulcerative colitis (UC), Crohn’s disease (CD), and unclassified IBDs. The pathogenesis of IBDs is related to genetic susceptibility, environmental factors, and dysbiosis that can lead to the dysfunction of immune responses and dysregulated homeostasis of local mucosal tissues characterized by severe inflammatory responses and tissue damage in GI tract. To date, extensive studies have indicated that IBDs cannot be completely cured and easy to relapse, thus prompting researchers to find novel and more effective therapeutics for this disease. Due to their potent multipotent differentiation and immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs) not only play an important role in regulating immune and tissue homeostasis but also display potent therapeutic effects on various inflammatory diseases, including IBDs, in both preclinical and clinical studies. In this review, we present a comprehensive overview on the pathological mechanisms, the currently available therapeutics, particularly, the potential application of MSCs-based regenerative therapy for IBDs. Frontiers Media S.A. 2022-08-04 /pmc/articles/PMC9386516/ /pubmed/35990688 http://dx.doi.org/10.3389/fimmu.2022.952071 Text en Copyright © 2022 Che, Ye, Zhang, Lin, Yang, Liang and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Che, Zhengping
Ye, Ziyu
Zhang, Xueying
Lin, Bihua
Yang, Weiqing
Liang, Yanfang
Zeng, Jincheng
Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title_full Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title_fullStr Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title_full_unstemmed Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title_short Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
title_sort mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386516/
https://www.ncbi.nlm.nih.gov/pubmed/35990688
http://dx.doi.org/10.3389/fimmu.2022.952071
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