In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative “superbugs”, including MDR K. pneumoniae. However, the emergence of polymyxin res...

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Detalles Bibliográficos
Autores principales: Chung, Wan Yean, Abdul Rahim, Nusaibah, Mahamad Maifiah, Mohd Hafidz, Hawala Shivashekaregowda, Naveen Kumar, Zhu, Yan, Wong, Eng Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386545/
https://www.ncbi.nlm.nih.gov/pubmed/35991875
http://dx.doi.org/10.3389/fphar.2022.880352

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