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Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with p53 Deficiency

Background: TP53 protein is lost or mutated in about half of all types of human cancers and small molecules to regulate mutant p53 repair, or interrupt ubiquitination degradation of p53 induced by E3-ubiquitin ligase Mdm2 have a potential application in clinical application. Methods: To inhibit the...

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Detalles Bibliográficos
Autores principales:	Jiang, Zong-Yuan, Hong, Jiang, Zhang, Ju-Hua, Wang, Xiao-Feng, Ma, Yu-Shui, Xiong, Zhang-Xia, Sun, Hao-Ran, Cheng, Cong, Xie, Bang-Zhu, Liu, Ji-Bin, Ouyang, Yang-Gang, Fu, Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386868/ https://www.ncbi.nlm.nih.gov/pubmed/35971329 http://dx.doi.org/10.1177/15330338221119745

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