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CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

BACKGROUND: Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibitor under development for the treatment of ankylosing spond...

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Detalles Bibliográficos
Autores principales:	Gaur, Rajula, Mensah, Kofi A., Stricker, Jason, Adams, Mary, Parton, Anastasia, Cedzik, Dorota, Connarn, Jamie, Thomas, Michael, Horan, Gerald, Schafer, Peter, Mair, Stuart, Palmisano, Maria, Ramírez-Valle, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386913/ https://www.ncbi.nlm.nih.gov/pubmed/35982464 http://dx.doi.org/10.1186/s13075-022-02850-6

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