Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

BACKGROUND: Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) coculture model to study the role of mechanical injury and inflamm...

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Detalles Bibliográficos
Autores principales: Dwivedi, Garima, Flaman, Lisa, Alaybeyoglu, Begum, Struglics, André, Frank, Eliot H., Chubinskya, Susan, Trippel, Stephen B., Rosen, Vicki, Cirit, Murat, Grodzinsky, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386988/
https://www.ncbi.nlm.nih.gov/pubmed/35982461
http://dx.doi.org/10.1186/s13075-022-02881-z

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