C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear. Furthermore, its potential as a therapeutic target to treat A...

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Detalles Bibliográficos
Autores principales: Gomez-Arboledas, Angela, Carvalho, Klebea, Balderrama-Gutierrez, Gabriela, Chu, Shu-Hui, Liang, Heidi Yahan, Schartz, Nicole D., Selvan, Purnika, Petrisko, Tiffany J., Pan, Miranda A., Mortazavi, Ali, Tenner, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386996/
https://www.ncbi.nlm.nih.gov/pubmed/35978440
http://dx.doi.org/10.1186/s40478-022-01416-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386996/
https://www.ncbi.nlm.nih.gov/pubmed/35978440
http://dx.doi.org/10.1186/s40478-022-01416-6

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