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Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives
Quantitative susceptibility mapping (QSM) is a powerful, non-invasive, magnetic resonance imaging (MRI) technique that relies on measurement of magnetic susceptibility. So far, QSM has been employed mostly to study neurological disorders characterized by iron accumulation, such as Parkinson’s and Al...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387036/ https://www.ncbi.nlm.nih.gov/pubmed/35978351 http://dx.doi.org/10.1186/s12968-022-00883-z |
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author | Aimo, Alberto Huang, Li Tyler, Andrew Barison, Andrea Martini, Nicola Saccaro, Luigi F. Roujol, Sébastien Masci, Pier-Giorgio |
author_facet | Aimo, Alberto Huang, Li Tyler, Andrew Barison, Andrea Martini, Nicola Saccaro, Luigi F. Roujol, Sébastien Masci, Pier-Giorgio |
author_sort | Aimo, Alberto |
collection | PubMed |
description | Quantitative susceptibility mapping (QSM) is a powerful, non-invasive, magnetic resonance imaging (MRI) technique that relies on measurement of magnetic susceptibility. So far, QSM has been employed mostly to study neurological disorders characterized by iron accumulation, such as Parkinson’s and Alzheimer’s diseases. Nonetheless, QSM allows mapping key indicators of cardiac disease such as blood oxygenation and myocardial iron content. For this reason, the application of QSM offers an unprecedented opportunity to gain a better understanding of the pathophysiological changes associated with cardiovascular disease and to monitor their evolution and response to treatment. Recent studies on cardiovascular QSM have shown the feasibility of a non-invasive assessment of blood oxygenation, myocardial iron content and myocardial fibre orientation, as well as carotid plaque composition. Significant technical challenges remain, the most evident of which are related to cardiac and respiratory motion, blood flow, chemical shift effects and susceptibility artefacts. Significant work is ongoing to overcome these challenges and integrate the QSM technique into clinical practice in the cardiovascular field. |
format | Online Article Text |
id | pubmed-9387036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93870362022-08-19 Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives Aimo, Alberto Huang, Li Tyler, Andrew Barison, Andrea Martini, Nicola Saccaro, Luigi F. Roujol, Sébastien Masci, Pier-Giorgio J Cardiovasc Magn Reson Review Quantitative susceptibility mapping (QSM) is a powerful, non-invasive, magnetic resonance imaging (MRI) technique that relies on measurement of magnetic susceptibility. So far, QSM has been employed mostly to study neurological disorders characterized by iron accumulation, such as Parkinson’s and Alzheimer’s diseases. Nonetheless, QSM allows mapping key indicators of cardiac disease such as blood oxygenation and myocardial iron content. For this reason, the application of QSM offers an unprecedented opportunity to gain a better understanding of the pathophysiological changes associated with cardiovascular disease and to monitor their evolution and response to treatment. Recent studies on cardiovascular QSM have shown the feasibility of a non-invasive assessment of blood oxygenation, myocardial iron content and myocardial fibre orientation, as well as carotid plaque composition. Significant technical challenges remain, the most evident of which are related to cardiac and respiratory motion, blood flow, chemical shift effects and susceptibility artefacts. Significant work is ongoing to overcome these challenges and integrate the QSM technique into clinical practice in the cardiovascular field. BioMed Central 2022-08-18 /pmc/articles/PMC9387036/ /pubmed/35978351 http://dx.doi.org/10.1186/s12968-022-00883-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Aimo, Alberto Huang, Li Tyler, Andrew Barison, Andrea Martini, Nicola Saccaro, Luigi F. Roujol, Sébastien Masci, Pier-Giorgio Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title | Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title_full | Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title_fullStr | Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title_full_unstemmed | Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title_short | Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives |
title_sort | quantitative susceptibility mapping (qsm) of the cardiovascular system: challenges and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387036/ https://www.ncbi.nlm.nih.gov/pubmed/35978351 http://dx.doi.org/10.1186/s12968-022-00883-z |
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