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An Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease

Nirmatrelvir is an orally available inhibitor of SARS-CoV-2 main protease (Mpro) and the main ingredient of PAXLOVID, a drug approved by FDA for high-risk COVID-19 patients. Recently, a rare natural mutation, H172Y, was found to significantly reduce nirmatrelvir’s inhibitory activity. As the COVID-1...

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Detalles Bibliográficos
Autores principales:	Clayton, Joseph, de Oliveira, Vinicius Martins, Ibraham, Mohamed Fouad, Sun, Xinyuanyuan, Mahinthichaichan, Paween, Shen, Mingzhe, Hilgenfeld, Rolf, Shen, Jana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387124/ https://www.ncbi.nlm.nih.gov/pubmed/35982652 http://dx.doi.org/10.1101/2022.07.31.502215

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