Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

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The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor, ACE2, to tightly bind WT-Spike-RBD and prevent viral entr...

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Detalles Bibliográficos
Autores principales: Remesh, Soumya G., Merz, Gregory E., Brilot, Axel F., Chio, Un Seng, Rizo, Alexandrea N., Pospiech, Thomas H., Lui, Irene, Laurie, Mathew T., Glasgow, Jeff, Le, Chau Q., Zhang, Yun, Diwanji, Devan, Hernandez, Evelyn, Lopez, Jocelyne, Pawar, Komal Ishwar, Pourmal, Sergei, Smith, Amber M., Zhou, Fengbo, DeRisi, Joseph, Kortemme, Tanja, Rosenberg, Oren S., Glasgow, Anum, Leung, Kevin K., Wells, James A., Verba, Kliment A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387132/
https://www.ncbi.nlm.nih.gov/pubmed/35982665
http://dx.doi.org/10.1101/2022.08.09.503400

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