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Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study
BACKGROUND: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academia Brasileira de Neurologia - ABNEURO
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387187/ https://www.ncbi.nlm.nih.gov/pubmed/35613209 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 |
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author | Stoco-Oliveira, Mileide Cristina Valente, Heloisa Balotari Vanzella, Laís Manata André, Larissa Borba Rodrigues, Mariana Viana Vanderlei, Franciele Marques de Carvalho, Augusto Cesinando Vanderlei, Luiz Carlos Marques |
author_facet | Stoco-Oliveira, Mileide Cristina Valente, Heloisa Balotari Vanzella, Laís Manata André, Larissa Borba Rodrigues, Mariana Viana Vanderlei, Franciele Marques de Carvalho, Augusto Cesinando Vanderlei, Luiz Carlos Marques |
author_sort | Stoco-Oliveira, Mileide Cristina |
collection | PubMed |
description | BACKGROUND: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. OBJECTIVE: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. METHODS: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. RESULTS: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms(2) and HFms(2) indices were observed in PG1 and PG2, compared with CG. CONCLUSIONS: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD. |
format | Online Article Text |
id | pubmed-9387187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Academia Brasileira de Neurologia - ABNEURO |
record_format | MEDLINE/PubMed |
spelling | pubmed-93871872022-12-08 Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study Stoco-Oliveira, Mileide Cristina Valente, Heloisa Balotari Vanzella, Laís Manata André, Larissa Borba Rodrigues, Mariana Viana Vanderlei, Franciele Marques de Carvalho, Augusto Cesinando Vanderlei, Luiz Carlos Marques Arq Neuropsiquiatr Article BACKGROUND: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. OBJECTIVE: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. METHODS: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. RESULTS: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms(2) and HFms(2) indices were observed in PG1 and PG2, compared with CG. CONCLUSIONS: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD. Academia Brasileira de Neurologia - ABNEURO 2022-05-20 /pmc/articles/PMC9387187/ /pubmed/35613209 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Article Stoco-Oliveira, Mileide Cristina Valente, Heloisa Balotari Vanzella, Laís Manata André, Larissa Borba Rodrigues, Mariana Viana Vanderlei, Franciele Marques de Carvalho, Augusto Cesinando Vanderlei, Luiz Carlos Marques Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title | Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full | Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_fullStr | Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full_unstemmed | Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_short | Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_sort | does length of time since diagnosis in parkinson’s disease influence heart rate variability? a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387187/ https://www.ncbi.nlm.nih.gov/pubmed/35613209 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0153 |
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