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Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment
Vinpocetine (VNP), a semisynthetic active pharmaceutical ingredient, is used for oral management of cerebrovascular diseases because of its ability to enhance the blood flow to the brain. However, despite that, the therapeutic application of VNP is restricted due to its reduced bioavailability and d...
Autores principales: | Aldawsari, Hibah M., Badr-Eldin, Shaimaa M., Assiri, Nourah Y., Alhakamy, Nabil A., Privitera, Anna, Caraci, Filippo, Caruso, Giuseppe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387308/ https://www.ncbi.nlm.nih.gov/pubmed/35975309 http://dx.doi.org/10.1080/10717544.2022.2110996 |
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