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Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria
It is debatable whether HIV-infected patients are at greater risk for hepatitis E virus (HEV) infection compared with healthy subjects. The reported anti-HEV seroprevalence among different groups in Bulgaria varied from 9.04% to 25.9%, but the information regarding the HIV population is still missin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387478/ https://www.ncbi.nlm.nih.gov/pubmed/35176255 http://dx.doi.org/10.1016/j.bjid.2022.102329 |
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author | Golkocheva-Markova, Elitsa Kevorkyan, Ani Raycheva, Ralitsa Ismailova, Chiydem Yoncheva, Viliana Tenev, Tencho Emilova, Radoslava Grigorova, Lyubomira Baltadzhiev, Ivan Komitova, Radka |
author_facet | Golkocheva-Markova, Elitsa Kevorkyan, Ani Raycheva, Ralitsa Ismailova, Chiydem Yoncheva, Viliana Tenev, Tencho Emilova, Radoslava Grigorova, Lyubomira Baltadzhiev, Ivan Komitova, Radka |
author_sort | Golkocheva-Markova, Elitsa |
collection | PubMed |
description | It is debatable whether HIV-infected patients are at greater risk for hepatitis E virus (HEV) infection compared with healthy subjects. The reported anti-HEV seroprevalence among different groups in Bulgaria varied from 9.04% to 25.9%, but the information regarding the HIV population is still missing. The aim of the present study was to evaluate hepatitis E seroprevalence among HIV-infected patients in Bulgaria and to analyze demographic and immunological factors associated with HEV infection. Serum samples of 312 HIV-infected patients were analyzed retrospectively. Age, sex, residence and laboratory markers for HEV, HBV, HCV and HIV infection, and lymphocytes subpopulations were collected for all patients. None of the tested samples were positive for HEV RNA. HEV seroprevalence among HIV-infected patients was 10.9%. Males were more affected with the highest prevalence of positivity in the age group > 30 to ≤ 40 years. The documented HIV transmission routes in HIV/HEV co-infected group were heterosexual, homosexual, intravenous drug use (IDU), and vertical with predominace of the heterosexual route (z = 0.2; p = 0.804). There was a statistically significant trend of HIV mixed infection with routes of HIV transmission other than homosexual - heterosexual in HIV/HEV group and injection drug use in HIV/HBV/HCV co-infected group. The route of HIV transmission, in contexts of patients’ behavior, was associated with HEV prevalence among HIV-infected patients. |
format | Online Article Text |
id | pubmed-9387478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93874782022-08-23 Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria Golkocheva-Markova, Elitsa Kevorkyan, Ani Raycheva, Ralitsa Ismailova, Chiydem Yoncheva, Viliana Tenev, Tencho Emilova, Radoslava Grigorova, Lyubomira Baltadzhiev, Ivan Komitova, Radka Braz J Infect Dis Original Article It is debatable whether HIV-infected patients are at greater risk for hepatitis E virus (HEV) infection compared with healthy subjects. The reported anti-HEV seroprevalence among different groups in Bulgaria varied from 9.04% to 25.9%, but the information regarding the HIV population is still missing. The aim of the present study was to evaluate hepatitis E seroprevalence among HIV-infected patients in Bulgaria and to analyze demographic and immunological factors associated with HEV infection. Serum samples of 312 HIV-infected patients were analyzed retrospectively. Age, sex, residence and laboratory markers for HEV, HBV, HCV and HIV infection, and lymphocytes subpopulations were collected for all patients. None of the tested samples were positive for HEV RNA. HEV seroprevalence among HIV-infected patients was 10.9%. Males were more affected with the highest prevalence of positivity in the age group > 30 to ≤ 40 years. The documented HIV transmission routes in HIV/HEV co-infected group were heterosexual, homosexual, intravenous drug use (IDU), and vertical with predominace of the heterosexual route (z = 0.2; p = 0.804). There was a statistically significant trend of HIV mixed infection with routes of HIV transmission other than homosexual - heterosexual in HIV/HEV group and injection drug use in HIV/HBV/HCV co-infected group. The route of HIV transmission, in contexts of patients’ behavior, was associated with HEV prevalence among HIV-infected patients. Elsevier 2022-02-15 /pmc/articles/PMC9387478/ /pubmed/35176255 http://dx.doi.org/10.1016/j.bjid.2022.102329 Text en © 2022 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Golkocheva-Markova, Elitsa Kevorkyan, Ani Raycheva, Ralitsa Ismailova, Chiydem Yoncheva, Viliana Tenev, Tencho Emilova, Radoslava Grigorova, Lyubomira Baltadzhiev, Ivan Komitova, Radka Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title | Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title_full | Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title_fullStr | Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title_full_unstemmed | Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title_short | Assessment of hepatitis E seropositivity among HIV-infected patients in Bulgaria |
title_sort | assessment of hepatitis e seropositivity among hiv-infected patients in bulgaria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387478/ https://www.ncbi.nlm.nih.gov/pubmed/35176255 http://dx.doi.org/10.1016/j.bjid.2022.102329 |
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