Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy

Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfide rebridging divinylpyrimidine technology, with bicyclononyne and methylcyclopropene handles to facilitate sequential SPAAC and IEDDA reactions....

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Detalles Bibliográficos
Autores principales: Hanby, Abigail R., Walsh, Stephen J., Counsell, Andrew J., Ashman, Nicola, Mortensen, Kim T., Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387566/
https://www.ncbi.nlm.nih.gov/pubmed/35912884
http://dx.doi.org/10.1039/d2cc02515a

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