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Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers

Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control,...

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Detalles Bibliográficos
Autores principales: Waheed, Qaiser, Zhou, Huimin, Ruoff, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387869/
https://www.ncbi.nlm.nih.gov/pubmed/35980978
http://dx.doi.org/10.1371/journal.pone.0262371
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author Waheed, Qaiser
Zhou, Huimin
Ruoff, Peter
author_facet Waheed, Qaiser
Zhou, Huimin
Ruoff, Peter
author_sort Waheed, Qaiser
collection PubMed
description Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics (“single-E controllers”), or by the removal of two control species by second-order kinetics (“antithetic or dual-E control”). In this paper we show results when the control species E(1) and E(2) in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed.
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spelling pubmed-93878692022-08-19 Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers Waheed, Qaiser Zhou, Huimin Ruoff, Peter PLoS One Research Article Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics (“single-E controllers”), or by the removal of two control species by second-order kinetics (“antithetic or dual-E control”). In this paper we show results when the control species E(1) and E(2) in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed. Public Library of Science 2022-08-18 /pmc/articles/PMC9387869/ /pubmed/35980978 http://dx.doi.org/10.1371/journal.pone.0262371 Text en © 2022 Waheed et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Waheed, Qaiser
Zhou, Huimin
Ruoff, Peter
Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title_full Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title_fullStr Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title_full_unstemmed Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title_short Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
title_sort kinetics and mechanisms of catalyzed dual-e (antithetic) controllers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387869/
https://www.ncbi.nlm.nih.gov/pubmed/35980978
http://dx.doi.org/10.1371/journal.pone.0262371
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