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Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387869/ https://www.ncbi.nlm.nih.gov/pubmed/35980978 http://dx.doi.org/10.1371/journal.pone.0262371 |
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author | Waheed, Qaiser Zhou, Huimin Ruoff, Peter |
author_facet | Waheed, Qaiser Zhou, Huimin Ruoff, Peter |
author_sort | Waheed, Qaiser |
collection | PubMed |
description | Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics (“single-E controllers”), or by the removal of two control species by second-order kinetics (“antithetic or dual-E control”). In this paper we show results when the control species E(1) and E(2) in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed. |
format | Online Article Text |
id | pubmed-9387869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93878692022-08-19 Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers Waheed, Qaiser Zhou, Huimin Ruoff, Peter PLoS One Research Article Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics (“single-E controllers”), or by the removal of two control species by second-order kinetics (“antithetic or dual-E control”). In this paper we show results when the control species E(1) and E(2) in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed. Public Library of Science 2022-08-18 /pmc/articles/PMC9387869/ /pubmed/35980978 http://dx.doi.org/10.1371/journal.pone.0262371 Text en © 2022 Waheed et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Waheed, Qaiser Zhou, Huimin Ruoff, Peter Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title | Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title_full | Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title_fullStr | Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title_full_unstemmed | Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title_short | Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers |
title_sort | kinetics and mechanisms of catalyzed dual-e (antithetic) controllers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387869/ https://www.ncbi.nlm.nih.gov/pubmed/35980978 http://dx.doi.org/10.1371/journal.pone.0262371 |
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