Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells

Buruli ulcer is a chronic skin disease caused by a toxic lipid mycolactone produced by Mycobacterium ulcerans, which induces local skin tissue destruction and analgesia. However, the cytotoxicity pathway induced by mycolactone remains largely unknown. Here we investigated the mycolactone-induced cel...

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Detalles Bibliográficos
Autores principales: Kawashima, Akira, Kiriya, Mitsuo, En, Junichiro, Tanigawa, Kazunari, Nakamura, Yasuhiro, Fujiwara, Yoko, Luo, Yuqian, Maruyama, Keiji, Watanabe, Shigekazu, Goto, Masamichi, Suzuki, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387930/
https://www.ncbi.nlm.nih.gov/pubmed/35939511
http://dx.doi.org/10.1371/journal.pntd.0010672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387930/
https://www.ncbi.nlm.nih.gov/pubmed/35939511
http://dx.doi.org/10.1371/journal.pntd.0010672

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