Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects

BACKGROUND: UV-4 (N-(9’-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in vivo efficacy against both dengue and influenza...

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Detalles Bibliográficos
Autores principales: Callahan, Michael, Treston, Anthony M., Lin, Grace, Smith, Marla, Kaufman, Brian, Khaliq, Mansoora, Evans DeWald, Lisa, Spurgers, Kevin, Warfield, Kelly L., Lowe, Preeya, Duchars, Matthew, Sampath, Aruna, Ramstedt, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387934/
https://www.ncbi.nlm.nih.gov/pubmed/35939501
http://dx.doi.org/10.1371/journal.pntd.0010636

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