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Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis

BACKGROUND: Endometrial scratching (ES) has demonstrated initial success in women with recurrent implantation failure, but the effect in women with 1 previous assisted reproductive technology (ART) failure is unknown. This meta-analysis aimed to evaluate the impact of ES as a treatment in clinical o...

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Autores principales: Kang, YiFan, Wang, ZhiHong, Yang, Yuan, Liang, HuiZhi, Duan, Xia, Gao, QingZhuo, Yin, ZhaoFang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387958/
https://www.ncbi.nlm.nih.gov/pubmed/35984122
http://dx.doi.org/10.1097/MD.0000000000030150
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author Kang, YiFan
Wang, ZhiHong
Yang, Yuan
Liang, HuiZhi
Duan, Xia
Gao, QingZhuo
Yin, ZhaoFang
author_facet Kang, YiFan
Wang, ZhiHong
Yang, Yuan
Liang, HuiZhi
Duan, Xia
Gao, QingZhuo
Yin, ZhaoFang
author_sort Kang, YiFan
collection PubMed
description BACKGROUND: Endometrial scratching (ES) has demonstrated initial success in women with recurrent implantation failure, but the effect in women with 1 previous assisted reproductive technology (ART) failure is unknown. This meta-analysis aimed to evaluate the impact of ES as a treatment in clinical outcomes for women with at least 1 failed in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)/Intrauterine Insemination (IUI). METHODS: PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were searched for randomized controlled trial studies utilizing endometrial scratching for infertility women with at least 1 failed assisted reproductive technology (ART) to collect pregnancy outcomes, including clinical pregnancy rate (CPR), embryo implantation rate (IR), miscarriage rate (MR), live birth rate (LBR), and multiple pregnancy rate (MPR). RESULTS: Sixteen randomized controlled trial (RCT) studies were included in this meta-analysis, including 1770 women in the intervention group and 1934 women in the control group. Overall, the CPR, IR and LBR were significantly higher in the intervention group than in the control group (for CPR, n = 1430, 16 studies, P = .0002, risk ratio (RR) = 1.59, 95% confidence interval [CI] [1.24, 2.03]; for IR, n = 859, 10 studies, P = .0003, RR = 1.67, 95% CI [1.26, 2.21]; for LBR, n = 156, 6 studies, P = .0005, RR = 1.59, 95% CI [1.22, 2.06]). Nonetheless, there was no significant difference in MR (n = 344, 11 studies, P = .62, risk ratio (RR) = 0.92, 95% confidence interval [CI] [0.66, 1.29]) and MPR (n = 98, 3 studies, P = .39, risk ratio (RR) = 0.81, 95% confidence interval [CI] [0.51, 1.30]) between the intervention group and the control group. CONCLUSION: Endometrial scratching is considered to enhance the reproductive outcomes of embryo implantation. Additional randomized controlled studies are recommended to identify the appropriate time of invasion and the applicable population to confirm whether it can become a routine operation.
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spelling pubmed-93879582022-08-23 Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis Kang, YiFan Wang, ZhiHong Yang, Yuan Liang, HuiZhi Duan, Xia Gao, QingZhuo Yin, ZhaoFang Medicine (Baltimore) Research Article BACKGROUND: Endometrial scratching (ES) has demonstrated initial success in women with recurrent implantation failure, but the effect in women with 1 previous assisted reproductive technology (ART) failure is unknown. This meta-analysis aimed to evaluate the impact of ES as a treatment in clinical outcomes for women with at least 1 failed in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)/Intrauterine Insemination (IUI). METHODS: PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were searched for randomized controlled trial studies utilizing endometrial scratching for infertility women with at least 1 failed assisted reproductive technology (ART) to collect pregnancy outcomes, including clinical pregnancy rate (CPR), embryo implantation rate (IR), miscarriage rate (MR), live birth rate (LBR), and multiple pregnancy rate (MPR). RESULTS: Sixteen randomized controlled trial (RCT) studies were included in this meta-analysis, including 1770 women in the intervention group and 1934 women in the control group. Overall, the CPR, IR and LBR were significantly higher in the intervention group than in the control group (for CPR, n = 1430, 16 studies, P = .0002, risk ratio (RR) = 1.59, 95% confidence interval [CI] [1.24, 2.03]; for IR, n = 859, 10 studies, P = .0003, RR = 1.67, 95% CI [1.26, 2.21]; for LBR, n = 156, 6 studies, P = .0005, RR = 1.59, 95% CI [1.22, 2.06]). Nonetheless, there was no significant difference in MR (n = 344, 11 studies, P = .62, risk ratio (RR) = 0.92, 95% confidence interval [CI] [0.66, 1.29]) and MPR (n = 98, 3 studies, P = .39, risk ratio (RR) = 0.81, 95% confidence interval [CI] [0.51, 1.30]) between the intervention group and the control group. CONCLUSION: Endometrial scratching is considered to enhance the reproductive outcomes of embryo implantation. Additional randomized controlled studies are recommended to identify the appropriate time of invasion and the applicable population to confirm whether it can become a routine operation. Lippincott Williams & Wilkins 2022-08-19 /pmc/articles/PMC9387958/ /pubmed/35984122 http://dx.doi.org/10.1097/MD.0000000000030150 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kang, YiFan
Wang, ZhiHong
Yang, Yuan
Liang, HuiZhi
Duan, Xia
Gao, QingZhuo
Yin, ZhaoFang
Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title_full Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title_fullStr Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title_full_unstemmed Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title_short Impact of endometrial scratching on reproductive outcome in patients: A systematic review and meta-analysis
title_sort impact of endometrial scratching on reproductive outcome in patients: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387958/
https://www.ncbi.nlm.nih.gov/pubmed/35984122
http://dx.doi.org/10.1097/MD.0000000000030150
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