Effect of the combined application of orthokeratology and single-vision spectacles on slowing the progression of high myopia: A systematic review and meta-analysis

PURPOSE: The purpose of the study was to conduct a meta-analysis about the effect of the combined application of orthokeratology and single-vision spectacles on slowing the progression of high myopia. METHODS: The literature was searched in PubMed, EMBASE, the Cochrane Library, Wang Fang Data, CNKI and sinoMed. The Cochrane Handbook was used to evaluate the quality of the included randomized clinical trials, and the Newcastle-Ottawa Scale was used to evaluate the included case–control or cohort studies. The results were analyzed by Revman 5.3. RESULTS: Five studies (2 randomized clinical trials, 2 case–controls, and 1 cohort study) with a total of 360 patients were included in this meta-analysis. The follow-up time was at least 1 year. Combined application of orthokeratology and single-vision spectacles were used in the experimental group. The control group used single-vision spectacles only. The pooled estimates indicated that the standardized mean difference between the 2 groups was –1.46 mm (95% confidence interval: –1.88 to –1.05; P < .05) for axial length elongation and –1.85D (95% confidence interval: –2.40 to –1.31; P < .05) for change in spherical equivalent refraction. No serious adverse events were reported in all studies. CONCLUSION: The combined application of orthokeratology and single-vision spectacles is more effective than single-vision spectacles only on slowing the progression of high myopia.