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Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

In Staphylococcus aureus, virulence is under the control of a quorum sensing (QS) circuit encoded in the accessory gene regulator (agr) genomic locus. Key to this pathogenic behavior is the production and signaling activity of a secreted pheromone, the autoinducing peptide (AIP), generated following...

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Detalles Bibliográficos
Autores principales:	Zhao, Aishan, Bodine, Steven P., Xie, Qian, Wang, Boyuan, Ram, Geeta, Novick, Richard P., Muir, Tom W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388083/ https://www.ncbi.nlm.nih.gov/pubmed/35939668 http://dx.doi.org/10.1073/pnas.2202661119

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