PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Pattern recognition molecules (PRMs) form an important part of innate immunity, where they facilitate the response to infections and damage by triggering processes such as inflammation. The pentraxin family of soluble PRMs comprises long and short pentraxins, with the former containing unique N-term...

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Detalles Bibliográficos
Autores principales: Noone, Dylan P., Dijkstra, Douwe J., van der Klugt, Teun T., van Veelen, Peter A., de Ru, Arnoud H., Hensbergen, Paul J., Trouw, Leendert A., Sharp, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388099/
https://www.ncbi.nlm.nih.gov/pubmed/35939690
http://dx.doi.org/10.1073/pnas.2208144119

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